The ED/SBS and HS IRBs KnowledgeBase (KB) pages will be retired over the remainder of the year. Much of the information from those sites has been relocated to the new IRB website or collated into the Investigator Manual, a comprehensive guide to the IRB review process and investigator responsibilities, and the Reliance Manual, a guide to collaborative research and single IRB review. The two manuals have been recently reformatted for improved access.