The Reliance and Navigation Team (RELIANT) assists researchers with collaborative and multi-site research issues, including helping identify the best single IRB review option for their studies and facilitating reliance agreements. We also support study teams in navigating institutional requirements that lie outside the IRB approval process.

To get assistance with either reliance or navigation issues, please contact us at We also provide consultations that can be requested through our consultation form.

The Reliance Manual (RM) provides comprehensive guidance about ceding IRB review, IRB of record arrangements, and ancillary review requirements. This is a draft manual and we welcome your feedback on how we can make the manual the best resource for you.