Analysis center studies apply to situations where the UW’s role is limited to analysis of data, samples, or images on behalf of a multi-site study. Only changes that affect procedures at UW-Madison require review and approval by the IRB. Examples of changes that affect local procedures include:

• Revisions to data transmission procedures
• Change in information associated with data, images, or samples provided to the UW-Madison or the type or source of data, images, or samples the UW-Madison will review
• Local personnel changes.
• Changes that do not directly affect the analysis center activities can be described at the time of continuing review.
• Research teams do not need to provide the revised documents (e.g., updated study-wide protocols or IDBs).