If UW-Madison will serve as the reviewing IRB for other sites, a standalone protocol is typically required.

Exceptions include minimal risk studies involving only one other site that do not involve interventions with subjects or subject interventions are limited in nature.

The IRB Toolkit’s HRP-503-TEMPLATE PROTOCOL -Biomedical and 503a-PROTOCOL TEMPLATE-Registries and Repositories include instructions for sections specifically addressing single IRB review requirement. Also see the Reliance Manual for guidance on multi-site research where UW-Madison is the reviewing IRB.